Synthesis of indenopyridine derivatives via MgI2-promoted [2+4] cycloaddition reaction of In-situ generated 2- styrylmalonate from donor-acceptor cyclopropanes and chalconimines

Abstract

An unexpected MgI2-promoted [2+4] cycloaddition reaction of in-situ generated 2-styrylmalonate from donor-acceptor cyclopropanes with chalconimines to synthesize highly substituted indenopyridine derivatives under the mild reaction conditions have been developed. Additionally, these derivatives were utilized for the synthesis of highly substituted 9-membered lactam by oxidative C=C bond cleavage and spiro [oxoindane-pyrrolidine] derivative via Meinwald type rearrangement.