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dc.contributor.authorMandal, P.-
dc.contributor.authorMalviya, N.-
dc.contributor.authorKundu, B.K.-
dc.contributor.authorDhankhar, S.S.-
dc.contributor.authorNagaraja, C.M.-
dc.contributor.authorMukhopadhyay, S.-
dc.date.accessioned2019-01-01T06:21:29Z-
dc.date.available2019-01-01T06:21:29Z-
dc.date.issued2019-01-01-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/1171-
dc.description.abstractThis work describes the synthesis of a series of Ru(II)‐Arene (Arene=p‐cymene, benzene) complexes using different N‐substituted tetrazole ligands and their PTA analogues. All the complexes have been characterized thoroughly using different analytical techniques. Antiproliferative activity of the synthesized complexes against different cell lines indicates remarkable activity of certain complexes up to nanomolar level. In few cases introduction of water soluble PTA (PTA = 1,3,5‐ triaza‐7‐phospha‐tricyclo‐[3.3.1.1]decane) ligand induce significant cytotoxic activity in the ruthenium complex with respect to their chloro analogues, particularly against Jurkat and MCF‐7 cell lines. Interaction with different biomolecules and stability of the RAPTA complexes have been explored in pseudo‐pharmacological conditions.en_US
dc.language.isoen_USen_US
dc.subjectAntiproliferative activityen_US
dc.subjectRAPTA complexesen_US
dc.subjectStability studyen_US
dc.subjectTetrazole scaffoldsen_US
dc.titleRAPTA complexes containing N‐substituted tetrazole scaffolds: synthesis, characterization and antiproliferative activityen_US
dc.typeArticleen_US
Appears in Collections:Year-2018

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