An assessment of electrophilic n-transfer of oxaziridine with different 2-, 3-, and 4-carbon donor–acceptor substrates to furnish diverse n-containing heterocycles in a single step

Abstract

An assessment of the scope and limitations of electrophilic N-transfer of oxaziridine in the presence of MgI2 has been carried out with different donor–acceptor carbon substrates. One step access to multifunctional three-, four-, and five-membered N-containing heterocycles has been demonstrated. The different donor and acceptor substituents present in the carbon substrates play a crucial role in determining the feasibility of the N-transfer process. This study portrays the possibilities to incorporate amine functionality in the molecules required for the synthesis of useful drug or modification of drug for a particular response. In addition, the generation of new stereocenters in the N-containing heterocycles through this single-step process offers favorable scopes for the synthesis of valuable drug molecules.