Chemoselective RuII-Catalyzed synthesis of aryl thiocyanates and Step-wise double [2+2+2] cycloadditions to 2-Aryl thiopyridines

Abstract

An atom-economical approach towards the synthesis of aryl thiocyanates has been documented employing ruthenium-catalyzed [2+2+2] cycloaddition strategy. Sequential RuII-catalyzed intermolecular [2+2+2] cycloadditions of 1,6-diynes and formed aryl thiocyanates resulted in the synthesis of 2-aryl thiopyridines. RuII-catalyzed intermolecular double [2+2+2] cycloadditions of 1,6-diynes and alkynylthiocyanates have been developed for the synthesis of 2-aryl thiopyridines. Aryl thiocyanates were isolated chemoselectively as a result of initial intermolecular [2+2+2] cycloaddition product. The method offers operational simplicity and is atom economical in nature.