Please use this identifier to cite or link to this item: http://dspace.iitrpr.ac.in:8080/xmlui/handle/123456789/2032
Title: Analysis of single-cell transcriptomes links enrichment of olfactory receptors with cancer cell differentiation status and prognosis
Authors: Kalra, S.
Mittal, A.
Gupta, K.
Singhal, V.
Gupta, A.
Mishra, T.
Naidu, S.
Sengupta, D.
Ahuja, G.
Issue Date: 7-Jul-2021
Abstract: Ectopically expressed olfactory receptors (ORs) have been linked with multiple clinicallyrelevant physiological processes. Previously used tissue-level expression estimation largely shadowed the potential role of ORs due to their overall low expression levels. Even after the introduction of the single-cell transcriptomics, a comprehensive delineation of expression dynamics of ORs in tumors remained unexplored. Our targeted investigation into single malignant cells revealed a complex landscape of combinatorial OR expression events. We observed differentiation-dependent decline in expressed OR counts per cell as well as their expression intensities in malignant cells. Further, we constructed expression signatures based on a large spectrum of ORs and tracked their enrichment in bulk expression profiles of tumor samples from The Cancer Genome Atlas (TCGA). TCGA tumor samples stratified based on OR-centric signatures exhibited divergent survival probabilities. In summary, our comprehensive analysis positions ORs at the cross-road of tumor cell differentiation status and cancer prognosis.
URI: http://localhost:8080/xmlui/handle/123456789/2032
Appears in Collections:Year-2020

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