EDA complex directed N-centred radical generation from nitrosoarenes: a divergent synthetic approach

Abstract

A metal-free strategy for the generation of N-centred radicals from nitrosoarenes (activated by allylsulfones) via electron donor–acceptor (EDA) complexes is reported. The EDA complex initiates a single electron transfer (SET) process via diisopropylethylamine (iPr2NEt) or a Hantzsch ester (HE). This mild and operationally simple protocol, initiated by the formation of a C–N bond, can conclude to either isoxazolidine or aziridine derivatives or can result in b-amino acid derivatives.