Please use this identifier to cite or link to this item: http://dspace.iitrpr.ac.in:8080/xmlui/handle/123456789/256
Title: A highly selective fluorescent ‘turn-on’ chemosensor for Hg2+ based on a phthalazin-hydrazone derivative and its application in human cervical cancer cell imaging†
Authors: Mahajan, D.
Khairnar, N.
Bondhopadhyay, B.
Sahoo, S.K.
Basu, A.
Singh, J.
Singh, N.
Bendre, R.
Kuwar, A.
Issue Date: 22-Aug-2016
Abstract: A new phthalazin-hydrazone based fluorescent chemosensor (E)-5-(diethylamino)-2-((2-(phthalazin-1-yl)hydrazono)methyl)phenol (1) was reported. Sensor 1 showed a high selectivity and sensitivity towards Hg2+ by giving significant fluorescence enhancement at 550 nm over other tested cations in DMSO/H2O (80[thin space (1/6-em)]:[thin space (1/6-em)]20, v/v) medium. The association constant was 1.0 × 104 M−1 between sensor 1 and Hg2+. Sensor 1 showed a nanomolar detection limit of 26.1 nM Hg2+. Finally, the fluorescence imaging experiments for the detection of intracellular Hg2+ in human cervical cancer HeLa cells showed its practical utility in biological samples.
URI: http://localhost:8080/xmlui/handle/123456789/256
Appears in Collections:Year-2015

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