Please use this identifier to cite or link to this item: http://dspace.iitrpr.ac.in:8080/xmlui/handle/123456789/2859
Title: Lewis Acid-Catalyzed [3+2] cycloaddition of Donor-Acceptor cyclopropanes and enamines: enantioselective synthesis of Nitrogen-Functionalized cyclopentane derivatives
Authors: Verma, K.
Banerjee, P.
Keywords: b-amino acids
donor-acceptor cyclopropanes
enamines
nitrogen-functionalized cyclopentanes
Issue Date: 3-Oct-2021
Abstract: A straightforward and efficient method for the synthesis of nitrogen-functionalized cyclopentane derivatives via [3+2] cycloaddition of enamines with donor-acceptor cyclopropanes in the presence of catalytic amounts of various Lewis acids at room temperature has been developed; furthermore, the corresponding b-amino acid was synthesized by monodecarboxylation and hydrogenolysis. An enantioenriched synthesis of nitrogen-functionalized cyclopentane derivatives through dynamic kinetic asymmetric transformation of racemic donor-acceptor cyclopropanes has also been achieved employingacopper complex [Cu(OTf)2 -L1] as the catalyst affording an enantiomeric ratio up to 8:1.
URI: http://localhost:8080/xmlui/handle/123456789/2859
Appears in Collections:Year-2016

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