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Title: | Organocatalytic enantioselective synthesis of C3 functionalized indole derivatives |
Authors: | Kaur, J. Islam, N. Kumar, A. Bhardwaj, V. K. Chimni, S. S. |
Keywords: | Organocatalysis Michael addition reaction Indolylnitroalkenes Enantioselective DFT |
Issue Date: | 4-Oct-2021 |
Abstract: | A highly enantioselective Michael addition reaction of indolylnitroalkenes with 1,3-dicarbonyl compounds has been developed to obtain enantiomerically enriched 3-(2-nitro-1-(1-tosyl-1H-indol-3-yl) ethyl)pentane-2,4-dione derivatives in up to 98% ee using BnCPN as an organocatalyst. The transition state structure has been predicted using DFT calculation |
URI: | http://localhost:8080/xmlui/handle/123456789/2883 |
Appears in Collections: | Year-2016 |
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