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dc.contributor.authorKumar, P.-
dc.date.accessioned2022-05-31T19:21:19Z-
dc.date.available2022-05-31T19:21:19Z-
dc.date.issued2022-06-01-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/3466-
dc.description.abstractHead and neck cancer detection using fluorescence spectroscopy from human saliva is reported here. This study has been conducted on squamous cell carcinoma (SCC), and dysplastic (precancer) and control (normal) groups using an in-house developed compact set-up. Fluorescence set-up consists of a 375-nm laser diode and optical components. Spectral bands of flavin adenine dinucleotide (FAD), porphyrins, and Raman are observed in the spectral range of 400 to 800 nm. Presence of FAD and porphyrin bands in human saliva is confirmed by the liquid phantoms of FAD and porphyrin. Significant differences in fluorescence intensities among all the three groups are observed. Three spectral ranges from 455 to 600, 605 to 770, and 400 to 800 nm are selected for each group and area values under each spectral range are computed. To differentiate among the groups, receiver operating characteristic (ROC) analysis is employed on the area values. ROC differentiates among the groups with accuracies of 98%, 92.85%, and 81.13% respectively in the spectral ranges of 400 to 800 nm. However, in other two spectral ranges (455 to 600 and 605 to 770 nm), low accuracy values are found. Obtained accuracy values indicate that selection of human saliva for head and neck cancer detection may be a good alternative.en_US
dc.language.isoen_USen_US
dc.subjectFlavin adenine dinucleotideen_US
dc.subjectFluorescenceen_US
dc.subjectHead and neck canceren_US
dc.subjectPorphyrinen_US
dc.subjectReceiver operating characteristic analysisen_US
dc.subjectSalivaen_US
dc.titleDetection of inaccessible head and neck lesions using human saliva and fluorescence spectroscopyen_US
dc.typeArticleen_US
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