Please use this identifier to cite or link to this item: http://dspace.iitrpr.ac.in:8080/xmlui/handle/123456789/3540
Title: α,β-Unsaturated Carbonyls for One-Pot Transition-Metal-Free Access to 3,6-Dihydro-2 H-pyrans
Authors: Kumar, P.
Kaur, N.
Kumar, R.
Banerjee, P.
Issue Date: 23-Jun-2022
Abstract: An efficient protocol has been developed for accessing mono-, di-, and trisubstituted 3,6-dihydro-2H-pyran derivatives by simply subjecting α,β-unsaturated carbonyls to the carefully optimized Corey-Chaykovsky reaction conditions. The strategy provides selectively substituted dihydropyran derivatives in good to excellent yields with a broad substrate scope under very mild reaction conditions. Easy transformation of the final 3,6-dihydro-2H-pyran to the valued 5,6-dihydro-2H-pyran-2-one and tetrahydro-2H-pyran derivatives expanded the scope of this methodology to diverse oxacycles. Further, the developed strategy also found application in a two-step route to racemic goniothalamin, which is widely studied for its cytotoxic behavior.
URI: http://localhost:8080/xmlui/handle/123456789/3540
Appears in Collections:Year-2022

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