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dc.contributor.authorRasool, N.-
dc.contributor.authorSrivastava, R.-
dc.contributor.authorSingh, Y.-
dc.date.accessioned2022-07-21T12:09:03Z-
dc.date.available2022-07-21T12:09:03Z-
dc.date.issued2022-07-21-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/3712-
dc.description.abstractAltered wound healing is a major challenge faced by both developed and developing nations. Biofilm formation has been identified as one of the causative factors for the progression of chronic wounds. The spread of biofilm is controlled by inhibiting the biofilm formation or disrupting the mature biofilm. Functional nanomaterials/enzymes with antimicrobial effects, such as metal oxides, rare earth metals, and carbon nanoparticles have been investigated to treat biofilm and overcome the drawbacks associated with the antibiotic therapy. Cerium oxide nanoparticles (CNPs) have drawn significant attention as a promising antimicrobial agent owing to their antibacterial, enzyme-mimetic, and crystalline properties but they suffer from poor colloidal stability and dispersity in an aqueous environment and size-dependent function. In this work, we have developed a functionalized silica ceria nanocomposite (FSC), as an antibiotic-free system, to treat biofilms. The FSC possesses a high surface area of mesoporous silica nanoparticles (MSNs) combined with the intrinsic antibacterial activity of cerium oxide for biofilm inhibition. The nanocomposite was fabricated using silica and ceria precursors, and it exhibited a high surface area of 436 m2/g and an average particle size of around 450 nm. The physical and chemical properties of nanocomposite were characterized using FTIR, XRD, UV–Vis, BET, EDX, and XPS analysis. It exhibited a potent antioxidant activity (86%), positive haloperoxidase mimetic property, and broad-spectrum antibacterial activities. It showed 99.9% inhibition against S. aureus (Gram-positive) and 81% inhibition against E. coli (Gram-negative) within 12 and 24 h along with the significant inhibition of biofilm formation (80%) as well as the disruptive effect against the established biofilm (77%) of S. aureus. Cell viability assays indicated the proliferative nature of composite in normal basal conditions and increased cell viability (97%) in the presence of oxidative stress. Despite being a cationic nanomaterial, it showed a good hemocompatibility against human blood and caused complete wound closure in mouse fibroblast cell line within 24 h. The functionalized silica ceria nanocomposite developed has a strong potential in chronic wound healing applications.en_US
dc.language.isoen_USen_US
dc.subjectAntibacterialen_US
dc.subjectAntibiofilmen_US
dc.subjectAntioxidanten_US
dc.subjectChronic woundsen_US
dc.subjectSilica ceria nanocompositeen_US
dc.titleCationized silica ceria nanocomposites to target biofilms in chronic woundsen_US
dc.typeArticleen_US
Appears in Collections:Year-2022

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