Please use this identifier to cite or link to this item: http://dspace.iitrpr.ac.in:8080/xmlui/handle/123456789/4057
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBhardwaj, G.-
dc.contributor.authorKaur, R.-
dc.contributor.authorSaini, S.-
dc.contributor.authorKaur, N.-
dc.contributor.authorSingh, N.-
dc.date.accessioned2022-09-26T07:24:31Z-
dc.date.available2022-09-26T07:24:31Z-
dc.date.issued2022-09-26-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/4057-
dc.description.abstractRegardless of the significant use of 5-bromo-20 -deoxyuridine (BrdU) as a radiosensitizer and diagnostic tool in cancer patients, some severe side effects and health issues have been reported, such as genetic mutations, birth defects, and other inheritable genetic effects. Thus, it has become more important to quantify the amount of BrdU during its usage. With reference to this, Ni@4H-chromene (Ni@G1)-based core–shell nanoparticles have been fabricated and these show a great response for the selective and sensitive detection of BrdU. The formed Ni@G1 exhibits no significant response with interfering thymidine analogs like iododeoxyuridine (EI) and ethynyl deoxyuridine (EdU) in competitive binding studies. Ni@G1 shows the ability to sense BrdU up to a detection limit of 9 nM and no significant interference is shown by pH, salt and temperature. A comparison of studies in aqueous and organic media further reveals that the sensor reported here shows an excellent response in an aqueous medium.en_US
dc.language.isoen_USen_US
dc.titleNi@4H-chromene-based core–shell nanoparticles: highly sensitive and selective chemosensors for the radiosensitizer bromodeoxyuridineen_US
dc.typeArticleen_US
Appears in Collections:Year-2022

Files in This Item:
File Description SizeFormat 
Full Text.pdf3.66 MBAdobe PDFView/Open    Request a copy


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.