Design, synthesis and antimicrobial evaluation of dihydropyrimidone based organic-inorganic nano-hybrids

Abstract

Substituted dihydropyrimidone derivatives were synthesized through one pot multicomponent Zn(ClO4)2 catalysed Biginelli reactions between differently substituted aromatic aldehydes, urea and ethylacetoacetate. Purified products were characterized and further engineered into metal inorganic conjugates of silver, copper and gold. Size, morphology and stability of nanoaggregates were analysed using FTIR, EDX, TEM, XRD and TGA analysis. Antimicrobial activities of all the synthesized compounds and their metal conjugates were evaluated against various bacterial and fungal strains. Results of investigations revealed that metal nanoaggregate Au@4c has shown maximum inhibition of MIC 8 against bacteria S. aureus. Further, bacterial SEM cell imaging carried out against S. aureus before and after treatment of Au@4c advocates that formation of blebs due to the accumulation of the cytoplasm are possible cause of bacterial cell death.