Please use this identifier to cite or link to this item: http://dspace.iitrpr.ac.in:8080/xmlui/handle/123456789/741
Title: An eco-friendly route to N-Arylindoles by iron-catalyzed [2+2+2] cycloaddition of diynes with (Indol-1-yl)alkynes
Authors: Chowdhury, H.
Chatterjee, N.
Goswami, A.
Keywords: Synthetic methods
Nitrogen heterocycles
Alkynes
Cycloaddition
Iron
Issue Date: 12-Dec-2016
Abstract: A new pathway to the synthesis of N-arylindoles has been developed that proceeds through an iron-catalyzed [2+2+2] cycloaddition reaction between diynes and indole-N-alkynes. The reaction is carried out in ethanol and employs a catalyst system that consists of iron(II) chloride tetrahydrate as the metal source, 2-[(2,6-diisopropylphenyl)iminomethyl]pyridine (dipimp) as the ligand, and zinc as the reducing agent. The method provides efficient access to 3-carbonyl/ ester-substituted (indol-1-yl)arenes in good to excellent yields under green reaction conditions, and these products are structurally similar to other N-arylindole derivatives with potential medicinal value.
URI: http://localhost:8080/xmlui/handle/123456789/741
Appears in Collections:Year-2015

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