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Browsing by Author "Pahari, S."

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Corrigendum: Curdlan Limits Mycobacterium tuberculosis Survival Through STAT-1 Regulated Nitric Oxide Production (Front. Microbiol., (2019), 10, (1173), 10.3389/fmicb.2019.01173)

Negi, S.; Pahari, S.; Das, D.K.; Khan, N.; Agarwala, J.N. (2022-11-20)

In the original article, there was a mistake in the legend for Figure 8 as published. We have corrected Figure 8B and the legend has also been corrected. The correct Figure 8 and legend appears below. In the original ...
Cumulative signaling through NOD-2 and TLR-4 eliminates the mycobacterium tuberculosis concealed inside the mesenchymal stem cells

Aqdas, M.; Singh, S.; Amir, M.; Maurya, S. K.; Pahari, S.; Agrewala, J. N. (2021-08-05)

For a long time, tuberculosis (TB) has been inﬂicting mankind with the highest morbidity and mortality. Although the current treatment is extremely potent, a few bacilli can still hide inside the host mesenchymal stem cells ...
Curdlan limits mycobacterium tuberculosissurvival through STAT-1 regulated nitric oxide production

Negi, S.; Pahari, S.; Das, D. K.; Khan, N.; Agrewala, J. N. (2021-08-30)

Host-directed therapies have emerged as an innovative and promising approach in tuberculosis (TB) treatment due to the observed limitations of current TB regimen such as lengthy duration and emergence of drug resistance. ...
Gut microbiota regulates mincle mediated activation of lung dendritic cells to protect against mycobacterium tuberculosis

Negi, S.; Pahari, S.; Bashir, H.; Agrewala, J. N. (2021-08-30)

Gut microbial components serve as ligand for various pattern recognition receptors (PRRs) present on immune cells and thereby regulates host immunity. Dendritic cells (DCs) are highly specialized innate cells involved in ...
Immunotherapeutic role of NOD-2 and TLR-4 signaling as an adjunct to antituberculosis chemotherapy

Aqdas, M.; Maurya, S.K.; Pahari, S.; Singh, S.; Khan, N.; Sethi, K.; Kaur, G.; Agrewala, J.N. (2022-08-18)

Tuberculosis (TB) treatment is lengthy and inflicted with severe side-effects. Here, we attempted a novel strategy to reinforce host immunity through NOD-like receptor (NOD-2) and Toll-like receptor (TLR-4) signaling in ...
Induction of autophagy through CLEC4E in combination with TLR4: an innovative strategy to restrict the survival of mycobacterium tuberculosis

Pahari, S.; Negi, S.; Aqdas, M.; Arnett, E.; Schlesinger, L. S.; Agrewala, J. N. (2021-07-07)

Host-directed therapies are gaining considerable impetus because of the emergence of drug-resistant strains of pathogens due to antibiotic therapy. Therefore, there is an urgent need to exploit alternative and novel ...
Intestinal microbiota disruption limits the isoniazid mediated clearance of mycobacterium tuberculosis in mice

Negi, S.; Pahari, S.; Bashir, H.; Agrewala, J. N. (2021-07-07)

Tuberculosis (TB) continues to remain a global threat due to the emergence of drug-resistant Mycobacterium tuberculosis (Mtb) strains and toxicity associated with TB drugs. Intestinal microbiota has been reported to affect ...
Potential role of gut microbiota in induction and regulation of innate immune memory

Negi, S.; Das, D. K.; Pahari, S.; Nadeem, S.; Agrewala, J. N. (2021-08-30)

The gut microbiota significantly regulates the development and function of the innate and adaptive immune system. The attribute of immunological memory has long been linked only with adaptive immunity. Recent evidence ...

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