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Browsing by Author "Pal, D."

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Cutaneous epithelial to mesenchymal transition activator ZEB1 regulates wound angiogenesis and closure in a glycemic status–dependent manner

Singh, K.; Sinha, M.; Pal, D.; Tabasum, S.; Gnyawali, S. C.; Khona, D.; Sarkar, S.; Mohanty, S. K.; Gonzalez, F. S.; Khanna, S.; Roy, S.; Sen, C. K. (2021-08-19)

Epithelial to mesenchymal transition (EMT) and wound vascularization are two critical interrelated processes that enable cutaneous wound healing. Zinc finger E-box binding homeobox 1 (ZEB1), primarily studied in the ...
Development of a multicellular 3D tumor model to study cellular heterogeneity and plasticity in NSCLC tumor microenvironment

Arora, L.; Kalia, M.; Dasgupta, S.; Singh, N.; Verma, A.K.; Pal, D. (2022-11-25)

Heterogeneity is a characteristic feature of solid tumors. Intra-tumor heterogeneity includes phenotypic diversity, epigenetic abnormalities, cell proliferation, and plasticity that eventually drives disease progression. ...
Dexamethasone-loaded, injectable pullulan-poly(ethylene glycol) hydrogels for bone tissue regeneration in chronic inflammatory conditions

Chauhan, N.; Gupta, P.; Arora, L.; Pal, D.; Singh, Y. (2021-10-25)

Chronic inflammation, infection, and fixation stability disrupts bone tissue regeneration by implants. The elevated levels of inflammatory markers and reactive oxygen species (ROS) damage tissues, inhibit osteoblastic ...
Genome-wide DNA hypermethylation opposes healing in patients with chronic wounds by impairing epithelialmesenchymal transition

Singh, K.; Roy, S.; Sen, C. K.; Rustag, Y.; Abouhashem, A.S.; Tabasum, S.; Verma, P.; Hernandez, E.; Khona, D.K.; Pal, D.; Mohanty, S.K.; Kumar, M.; Srivastava, R.; Guda, P.R.; Verma, S.S.; Mahajan, S.; Killian, J.A.; Walker, L. A.; Ghatak, S.; Mathew-Steiner, S.S.; Wanczyk, K.E.; Liu, S.; Wan, J.; Yan, P.; Bundschuh, R.; Khanna, G. M.; Murphy, M.P. (2022-10-27)

An extreme chronic wound tissue microenvironment causes epigenetic gene silencing. An unbiased whole-genome methylome was studied in the wound-edge tissue of patients with chronic wounds. A total of 4,689 differentially ...
Inflammation-induced mTORC2-Akt-mTORC1 signaling promotes macrophage foam cell formation

Banerjee, D.; Sinha, A.; Saikia, S.; Gogoi, B.; Rathore, B.; Das, A.S.; Pal, D.; Buragohain, A.K.; Dasgupta, S. (2018-08-30)

The transformation of macrophages into lipid-loaded foam cells is a critical and early event in the pathogenesis of atherosclerosis. Several recent reports highlighted that induction of TLR4 signaling promotes macrophage ...
Lipid-induced monokine cyclophilin-A promotes adipose tissue dysfunction implementing insulin resistance and type 2 diabetes in zebrafish and mice models of obesity

Banerjee, D.; Patra, D.; Sinha, A.; Roy, S.; Pant, R.; Sarmah, R.; Dutta, R.; Kanta Bhagabati, S.; Tikoo, K.; Pal, D.; Dasgupta, S. (2022-07-20)

Several studies have implicated obesity-induced macrophage–adipocyte cross-talk in adipose tissue dysfunction and insulin resistance. However, the molecular cues involved in the cross-talk of macrophage and adipocyte causing ...
Novel imidazo[1,2-a]pyridine derivatives induce apoptosis and cell cycle arrest in non-small cell lung cancer by activating NADPH oxidase mediated oxidative stress

Bhavya, K.; Mantipally, M.; Roy, S.; Arora, L.; Badavath, V.N.; Gangireddy, M.; Dasgupta, S.; Gundla, R.; Pal, D. (2022-07-21)

Imidazo[1,2-a]pyridine-based analogues have recently gained significant interest because of their wide spectrum of biological activities including anti-cancer potential, however the development of targeted therapeutic ...
Remodeling of stromal cells and immune landscape in microenvironment during tumor progression

Arora, L.; Pal, D. (2021-07-22)

The molecular understanding of carcinogenesis and tumor progression rests in intra and inter-tumoral heterogeneity. Solid tumors confined with vast diversity of genetic abnormalities, epigenetic modifications, and ...
Two-dimensional MoS2-based electrochemical biosensor for highly selective detection of glutathione

Rawat, B.; Mishra, K. K.; Barman, U.; Arora, L.; Pal, D.; Paily, R. P. (2021-06-12)

Glutathione (GSH) recently emerges as an important biomarker for cancers and various disease detection as its concentration varies in the µM to mM range in biological cells and fluids. Despite extensive efforts devoted ...

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