One-pot synthesis of tricyclic dihydropyrimidine derivatives and their biological evaluation

dc.contributor.author	Kaur, N.
dc.contributor.author	Kaur, K.
dc.contributor.author	Raj, T.
dc.contributor.author	Kaur, G.
dc.contributor.author	Singh, A.
dc.contributor.author	Aree, T.
dc.contributor.author	Park, S-J.
dc.contributor.author	Kim, T-J.
dc.contributor.author	Singh, N.
dc.contributor.author	Jange, D.O.
dc.date.accessioned	2016-07-25T11:45:18Z
dc.date.available	2016-07-25T11:45:18Z
dc.date.issued	2016-07-25
dc.identifier.uri	http://localhost:8080/xmlui/handle/123456789/108
dc.description.abstract	A series of tricyclic dihydropyrimidine derivatives were synthesized using a one-pot, three-component Traube–Schwarz reaction in the presence of catalyst Zn(ClO4)2·6H2O. All the purified compounds were evaluated for their in vitro anticancer activity against three different cancer cell lines such as prostate cancer cells (PC3), lung cancer cells (NCI-H1299) and colon cancer cells (HCT116). In vitro DNA-intercalation ability of the compounds was investigated by UV–vis absorption spectroscopy, showing the insertion of compound into the DNA base pairs and a strong interaction with the DNA double helix.	en_US
dc.language.iso	en_US	en_US
dc.subject	Dihydropyrimidine	en_US
dc.subject	One-pot	en_US
dc.subject	Anticancer	en_US
dc.subject	Traube–Schwarz reaction	en_US
dc.subject	Multi-component reaction	en_US
dc.subject	DNA binding	en_US
dc.title	One-pot synthesis of tricyclic dihydropyrimidine derivatives and their biological evaluation	en_US
dc.type	Article	en_US