Palladium(II)/N-Heterocyclic carbene catalyzed One-Pot sequential α-Arylation/Alkylation: access to 3,3-Disubstituted oxindoles

Abstract

Rationally designed fluorene-based mono- and bimetallic Pd−PEPPSI complexes were synthesized and demonstrated to be effective for the one-pot sequential α-arylation/alkylation of oxindoles. This streamlined approach offers efficient access to functionalized 3,3-disubstituted oxindoles in excellent yields (up to 89%) under mild reaction conditions.