Abstract:
This work describes the synthesis of a series of Ru(II)‐Arene (Arene=p‐cymene,
benzene) complexes using different N‐substituted tetrazole ligands and their
PTA analogues. All the complexes have been characterized thoroughly using
different analytical techniques. Antiproliferative activity of the synthesized
complexes against different cell lines indicates remarkable activity of certain
complexes up to nanomolar level. In few cases introduction of water soluble
PTA (PTA = 1,3,5‐ triaza‐7‐phospha‐tricyclo‐[3.3.1.1]decane) ligand induce significant cytotoxic activity in the ruthenium complex with respect to their chloro
analogues, particularly against Jurkat and MCF‐7 cell lines. Interaction with
different biomolecules and stability of the RAPTA complexes have been
explored in pseudo‐pharmacological conditions.
