Abstract:
Osteogenesis imperfecta (OI) is a genetic connective tissue disorder characterized by
skeletal deformity and increased risk of fracture. Independent mobility is of concern for OI patients
as it is associated with the quality of life. The present study investigates the variation of kinetic
and kinematic gait parameters of type IV OI subjects and compares them with age-matched healthy
subjects. Materials and Methods: Gait analysis is performed on five type IV OI patients and six
age-matched normal subjects. Spatiotemporal, kinematic, and kinetic data are obtained using Helen
Hayes marker placement protocol. Results: The results indicate an imprecise double-humped profile
for vertical ground reaction force (GRF) with reduced ankle push off power and walking speed for
OI subjects. Moreover, a comparison of vertical GRFs in OI subjects with that of healthy subjects
suggests lower values for the former. The results encourage and motivate for further investigation
with a bigger set of subjects. Conclusion: This information may be useful in developing a better
understanding of pathological gait in type IV OI subjects, which ultimately helps the design of
subject-specific implants, surgical preplanning, and rehabilitation.
