Abstract:
An assessment of the scope and limitations of electrophilic
N-transfer of oxaziridine in the presence of MgI2 has
been carried out with different donor–acceptor carbon substrates.
One step access to multifunctional three-, four-, and
five-membered N-containing heterocycles has been demonstrated.
The different donor and acceptor substituents present
in the carbon substrates play a crucial role in determining the feasibility of the N-transfer process. This study portrays the possibilities
to incorporate amine functionality in the molecules required
for the synthesis of useful drug or modification of drug
for a particular response. In addition, the generation of new
stereocenters in the N-containing heterocycles through this
single-step process offers favorable scopes for the synthesis of
valuable drug molecules.
