Abstract:
Nitrogen-containing molecules are the key
structural constituent of many pharmaceutical compounds that play a pivotal role in drug development.
Owing to their multifaceted medicinal importance,
several synthetic approaches have been delineated in
the recent past for their construction. Over the past
few decades the augmented use of donor–acceptor
cyclopropanes (DACs) as three-carbon synthetic
equivalents, despite their ring strain, for the construction of innumerable hetero- and carbocycles of
pharmaceutical importance has raised the interest of
synthetic chemists to this topic. Owing to their zwitterionic nature due to the vicinal disposition of
donor and acceptor groups, they have been frequently used in ring-opening reactions, cycloadditions, and
rearrangements. This review is mainly focused on assorted reactions of DACs with various nitrogen-containing dipolarophiles like imines, azides, cyanates,
isothiocyanates, nitrosocarbonyls, hydrazines, diaziridines, triazinanes, diazenes, etc. towards the synthesis
of nitrogen-containing molecules of pharmaceutical
and industrial importance. This review is in continuation of our review published in the Israel Journal of
Chemistry in April 2016, and includes the literature
from April 2016 to May 2019.
