Abstract:
This work deals with synthesis of new ferrocenamide ligands i.e. pyridine-2-carboxylic acid(4-ferrocenyl
aniline)-amide, HL1 and quinoline-1-carboxylic acid(4-ferrocenyl aniline)-amide, HL2 and two new
heterobimetallic Ru(II)-arene complexes of general formula [Ru(L)(h6
-arene)Cl] using synthesized ferrocenamide ligands (L1 ¼ pyridine-2-carboxylic acid(4-ferrocenyl aniline)-amide, h6
-arene ¼ p-cymene
1, and L2 ¼ quinoline-1-carboxylic acid(4-ferrocenyl aniline)-amide, h6
-arene ¼ p-cymene 3). These
chloro-complexes have been substituted with 1,3,5-triaza-7-phosphoadamantane (PTA) which produce
water soluble complexes of general formula [Ru(L)(h6
-arene)(PTA)]þ [2, 4]. All the complexes have been
characterized thoroughly with different analytical tools and their antiproliferative activities have been
evaluated against different cancerous cell lines. Among them, compound 3 has shown promising antiproliferative activity against all the cell lines, owing to its lower stability than the other complexes in
solution as well as ability to interact with different biomolecules, which makes it a potential candidate as
anticancer drug to investigate further.
