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Analysis of single-cell transcriptomes links enrichment of olfactory receptors with cancer cell differentiation status and prognosis

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dc.contributor.author Kalra, S.
dc.contributor.author Mittal, A.
dc.contributor.author Gupta, K.
dc.contributor.author Singhal, V.
dc.contributor.author Gupta, A.
dc.contributor.author Mishra, T.
dc.contributor.author Naidu, S.
dc.contributor.author Sengupta, D.
dc.contributor.author Ahuja, G.
dc.date.accessioned 2021-07-06T18:55:53Z
dc.date.available 2021-07-06T18:55:53Z
dc.date.issued 2021-07-07
dc.identifier.uri http://localhost:8080/xmlui/handle/123456789/2032
dc.description.abstract Ectopically expressed olfactory receptors (ORs) have been linked with multiple clinicallyrelevant physiological processes. Previously used tissue-level expression estimation largely shadowed the potential role of ORs due to their overall low expression levels. Even after the introduction of the single-cell transcriptomics, a comprehensive delineation of expression dynamics of ORs in tumors remained unexplored. Our targeted investigation into single malignant cells revealed a complex landscape of combinatorial OR expression events. We observed differentiation-dependent decline in expressed OR counts per cell as well as their expression intensities in malignant cells. Further, we constructed expression signatures based on a large spectrum of ORs and tracked their enrichment in bulk expression profiles of tumor samples from The Cancer Genome Atlas (TCGA). TCGA tumor samples stratified based on OR-centric signatures exhibited divergent survival probabilities. In summary, our comprehensive analysis positions ORs at the cross-road of tumor cell differentiation status and cancer prognosis. en_US
dc.language.iso en_US en_US
dc.title Analysis of single-cell transcriptomes links enrichment of olfactory receptors with cancer cell differentiation status and prognosis en_US
dc.type Article en_US


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