dc.description.abstract |
An anion-mediated preorganization approach was
used to design and synthesize the benzimidazolium-based
calix compound R1·2 ClO4
@
. X-ray crystallography analysis revealed that the hydrogen-bonding interactions between the
benzimidazolium cations and N,N-dimethylformamide (DMF)
helped R1·2 ClO4
@
encapsulate DMF molecule(s). A nanoreactor, with R1·2 ClO4
@
and l-histidine (l-His) as the components, was fabricated by using a neutralization method. The
nanoreactor could detoxify paraoxon in 30 min. l-His played
a vital role in this process. Paraoxonase is a well-known
enzyme used for pesticide degradation. The Ellman’s reagent
was used to determine the percentage inhibition of the
acetylcholinesterase (AChE) activity in the presence of the
nanoreactor. The results indicated that the nanoreactor inhibited AChE inhibition. |
en_US |