Abstract:
Fluorescence methods have gained enormous attention due to their ease in use, simplicity, selectivity and sensitivity.
Fluorescent chemosensors respond instantly by converting molecular
recognition to fluorescent signals. The consumption of pharmaceutical products by living beings is on great increase. The disposal of such
compounds in the environment is a matter of great concern as these
compounds enter aquatic environment and show accumulation in
tissues of aquatic organisms. In the present study, we have utilized
naphthalimide based receptors to fabricate organic nanoparticles
(ONPs). These ONPs were used for the development of hybrid
nanoassemblies, and the developed nanoassemblies were characterized with the help of transmission electron microscopy and dynamic
light scattering studies. The photophysical studies were performed
and the hybrid assembly developed using receptor 2 demonstrated a
turn-on fluorescence emission behavior on binding with Amitriptyline. The present sensing system acted as promising candidate
for determination of Amitriptyline among other contending drug molecules. The established system can recognize Amitriptyline
up to a detection limit of 48 nM in aqueous medium. Electrochemical recognition studies show binding of hybrid nanoassembly
of receptor 2 with Amitriptyline with limit of detection of 21 nM.
