A highly selective fluorescent ‘turn-on’ chemosensor for Hg2+ based on a phthalazin-hydrazone derivative and its application in human cervical cancer cell imaging†

dc.contributor.author	Mahajan, D.
dc.contributor.author	Khairnar, N.
dc.contributor.author	Bondhopadhyay, B.
dc.contributor.author	Sahoo, S.K.
dc.contributor.author	Basu, A.
dc.contributor.author	Singh, J.
dc.contributor.author	Singh, N.
dc.contributor.author	Bendre, R.
dc.contributor.author	Kuwar, A.
dc.date.accessioned	2016-08-22T07:00:58Z
dc.date.available	2016-08-22T07:00:58Z
dc.date.issued	2016-08-22
dc.identifier.uri	http://localhost:8080/xmlui/handle/123456789/256
dc.description.abstract	A new phthalazin-hydrazone based fluorescent chemosensor (E)-5-(diethylamino)-2-((2-(phthalazin-1-yl)hydrazono)methyl)phenol (1) was reported. Sensor 1 showed a high selectivity and sensitivity towards Hg2+ by giving significant fluorescence enhancement at 550 nm over other tested cations in DMSO/H2O (80[thin space (1/6-em)]:[thin space (1/6-em)]20, v/v) medium. The association constant was 1.0 × 104 M−1 between sensor 1 and Hg2+. Sensor 1 showed a nanomolar detection limit of 26.1 nM Hg2+. Finally, the fluorescence imaging experiments for the detection of intracellular Hg2+ in human cervical cancer HeLa cells showed its practical utility in biological samples.	en_US
dc.language.iso	en_US	en_US
dc.title	A highly selective fluorescent ‘turn-on’ chemosensor for Hg2+ based on a phthalazin-hydrazone derivative and its application in human cervical cancer cell imaging†	en_US
dc.type	Article	en_US