Abstract:
To address the issues allied with cardiovascular diseases and the
increased prevalence of hypertension, a novel electrochemical sensor
was developed based on poly(ionic liquid) [PVIM]–cobalt polyoxometalate (Co5POM) supported on carbonaceous materials (MNCs) for
the highly selective and ultrasensitive non-enzymatic detection of
cholesterol. The novel composite exhibits excellent selectivity and
sensitivity towards the non-enzymatic electrochemical detection of
cholesterol with a low detection limit of 1 fM (1 1015 M), a response
time of B5 s, and a wide detection range of 1 fM–5 mM with two
linear ranges of 1 fM–200 nM and 0.5 lM–5 mM with sensitivities of
210 and 64 lA lM1 cm2
, respectively, even in the presence of
ascorbic acid, glucose and uric acid. The proposed sensor was tested
with a human blood serum sample at physiological pH in a physiologically relevant concentration range. A novel flexible sensor was
developed with PVIM–Co5POM/MNC coated over Whatman filter
paper and this shows a high sensitivity with a wide detection range
of 1 fM–5 mM.
