Abstract:
Cancer is one of the major health problem globally, responsible for high morbidity
and mortality. Exposure of humans to xenobiotics is associated with the development
of cancer. Further, these xenobiotics may combine with the body proteins and can act
as a hapten and elicit an antibody response. In this study, we examined whether the
regular exposer to xenobiotics evokes anti-xenobiotic antibodies and the presence of
these antibodies have any correlation with the prevention of cancer. Interestingly, we
noticed that the healthy household contacts showed significantly greater titers of
anti-xenobiotic antibodies, as compared to cancer patients. Consequently, suggesting
that the higher level of anti-xenobiotic antibodies may be responsible for neutralizing
the effect of xenobiotics in the healthy subjects. Thereby, preventing the individuals
from disease. In contrast, the presence of a significantly lower level of anti-xenobiotic
antibodies in the cancer patients may be a causative factor for disease infliction. In
conclusion, immunotherapy employing anti-xenobiotic antibodies may provide a
prudent remedial measure to clear xenobiotics from the body of the individuals and
thereby protecting from cancer.
