Abstract:
Organic nanoparticles (ONPs) of lipoic acid and its doped derivatives ONPs/Ag
and ONPs/Au were prepared and characterized by UV-Visible, EDS, and TEM analysis. The
antibacterial properties of the ONPs ONPs/Ag and ONPs/Au were tested against bacterial
strains (Staphylococcus aureus, Bacillus cereus, Escherichia coli and Salmonella typhi).
Minimal Inhibitory Concentration (MIC) and bacterial growth inhibition tests show that
ONPs/Ag are more effective in limiting bacterial growth than other NPs, particularly, for
Gram positive than for Gram-negative ones. The order of bacterial cell growth inhibition
was ONPs/Ag > ONPs > ONPs/Au. The morphology of the cell membrane for the treated
bacteria was analyzed by SEM. The nature of bond formation of LA with Ag or Au was
analyzed by molecular orbital and density of state (DOS) using DFT.
