A quick access to 1-(2-Pyridyl)indoles via Solvent-Free Ruthenium(II)-Catalyzed Chemo- and regioselective [2+2+2] cycloaddition of α,ω-Diynes and N-Cyanoindoles

dc.contributor.author	Chowdhury, H.
dc.contributor.author	Goswami, A.
dc.date.accessioned	2021-10-11T06:45:56Z
dc.date.available	2021-10-11T06:45:56Z
dc.date.issued	2021-10-11
dc.identifier.uri	http://localhost:8080/xmlui/handle/123456789/3007
dc.description.abstract	A new route to synthesize 1-(2-pyridyl)indole scaffolds via the solvent-free, ruthenium(II)-catalyzed, chemo- and regioselective [2+2+2] cycloaddition reaction of diynes with N-cyanoindoles has been developed with good to excellent yields. Among the various transition metal-based catalysts known for cycloaddition reaction to synthesize pyridine derivatives, chloro(pentamethylcyclopentadienyl)(cyclooctadiene)ruthenium(II) was established to be the best catalyst for this system. This efficient methodology provides 3-substituted 1-(2-pyridyl)indole scaffolds having very close structural similarity with biological drug molecules.	en_US
dc.language.iso	en_US	en_US
dc.subject	[2+2+2] cycloaddition	en_US
dc.subject	N-cyanoindoles	en_US
dc.subject	diynes	en_US
dc.subject	N-heteroarylindoles	en_US
dc.subject	ruthenium catalyst	en_US
dc.title	A quick access to 1-(2-Pyridyl)indoles via Solvent-Free Ruthenium(II)-Catalyzed Chemo- and regioselective [2+2+2] cycloaddition of α,ω-Diynes and N-Cyanoindoles	en_US
dc.type	Article	en_US