Abstract:
A convenient, solvent free strategy for the synthesis of bis-coumarins has been developed using
zwitterionic liquid (ZIL) coated copper oxide (CuO) and mechanical ball milling. The ZIL were fabricated
from imidazolium/benzimidazolium and sulfonate/carboxylate based moieties. Use of the ZIL offers an
interesting multifunctional opportunity to immobilize them over CuO using the anionic part and the
cationic part is left freely available for use in catalytic applications. The hybrid catalysts were fully
characterized using scanning electron microscopy, transmission electron microscopy, energy-dispersive
X-ray spectroscopy, powder X-ray diffraction, cyclic voltammetry, solid state ultraviolet-visible absorption and
spectroscopic emission methods. The three ZIL-based and CuO coupled hybrid catalysts (ZIL@CuO1–3)
generated were found to have diverse sizes, shapes, photophysical signatures and electrochemical properties. The supramolecular assembly of ZIL and CuO in ZIL@CuO1 has extensively enhanced catalytic
activity compared to their individual parent components as well as to the two other hybrid materials,
ZIL@CuO2–3. The reaction conditions were optimized by varying the number of balls used, the milling
time and the milling speed. The reaction mechanism was elucidated using proton–nuclear magnetic
spectroscopy and all the final products were fully characterized using spectroscopic methods. Finally,
the performance of the reaction at the multigram scale is also detailed and a high EcoScale score and
a low E-factor are the most pleasing features of this methodology, and thus, authenticate its use
for eco-friendly synthesis of bis-coumarins and offer advancements over other catalysts described in
the literature.
