Stereoselective organocatalytic synthesis of γ, γ -disubstituted butenolides

dc.contributor.author	Sharma, V.
dc.contributor.author	Bhardwaj, V. K.
dc.contributor.author	Chimni, S. S.
dc.date.accessioned	2021-10-18T13:13:41Z
dc.date.available	2021-10-18T13:13:41Z
dc.date.issued	2021-10-18
dc.identifier.uri	http://localhost:8080/xmlui/handle/123456789/3074
dc.description.abstract	A direct highly diastereo- and enantioselective asymmetric doubly vinylogous 1,6-Michael addition reaction of 3-methyl-4- nitro-5-alkenyl isoxazoles with g-substituted deconjugated butenolides has been successfully developed with the help of Cinchona derived squaramides. This novel strategy has been utilized to synthesize a range of enantiopure g,g-disubstituted butenolide molecules bearing remote contiguous quaternary and tertiary stereocenters in yield up to 76% with ee up to 98% and dr up to 20:1.	en_US
dc.language.iso	en_US	en_US
dc.title	Stereoselective organocatalytic synthesis of γ, γ -disubstituted butenolides	en_US
dc.type	Article	en_US