Abstract:
Background: Over the last two decades, humanity has observed the extraordinary anomaly caused by
novel, weird coronavirus strains, such as severe acute respiratory syndrome (SARS) and Middle East
respiratory syndrome (MERS). As the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
virus has made its entry into the world, it has dramatically affected life in every domain by continuously
producing new variants. The vaccine development is an ongoing process, although some vaccines got
marketed. The big challenge is now whether the vaccine candidates can provide long-lasting protection
or prevention against mutant variants.
Methods: The information was gathered from various journals, electronic searches via Internet-based
information such as PubMed, Google Scholar, Science Direct, online electronic journals, WHO landscape,
world meters, WHO website, and News.
Results: This review will present and discuss some coronavirus disease 19 (COVID-19) related aspects
including: the pathophysiology, epidemiology, mutant variants vaccine candidates, vaccine efficacy, and
