Abstract:
Gold complexes of 1,3- bis-pyridylimidazolium chloride (L1
), 1,3-bis-[2,6-diisopropylphenyl]imidazolium chloride (L2
) and
1,3-bis-[benzyl]benzimidazolium chloride (L3
) were synthesized and characterized by analytical methods. For the complexes,
electronic spectral results show that there is a marked difference in the band feature observed in the spectra, ascribed to the
greater relativistic effect of gold. In fluorescence studies, the complexes develop emission bands in the visible region (400–600 nm)
after excitation at around 350 nm. Au complex–DNA binding was studied, and it was observed that genomic DNA isolated from the
U373-GB cell line was fragmented and in some cases degraded by the Au complexes. Furthermore, the intensity of the DNA band
increased when concentration of the metal complex was augmented. This study shows that the DNA cleavage is mediated by the
Au complex. Copyright
