Abstract:
Strain in the ring engenders versatile reactivity
that can be utilized for the synthesis of complex molecules
by the assimilation of suitable substituents. In this context,
vicinal donor-acceptor cyclopropanes (DACs) serve as threecarbon synthetic equivalents in organic synthesis from the
last few decades. Owing to their zwitterionic nature, they
have been frequently utilized in [3+n]-annulation reactions
with different dipolarophiles like aldehydes, imines, oximes,
epoxides, aziridines, etc. This review highlights developed
synthetic tools for annulation reactions of vicinal donor-acceptor cyclopropanes with saturated and unsaturated heterocyclic compounds.
