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Detection of inaccessible head and neck lesions using human saliva and fluorescence spectroscopy

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dc.contributor.author Kumar, P.
dc.date.accessioned 2022-05-31T19:21:19Z
dc.date.available 2022-05-31T19:21:19Z
dc.date.issued 2022-06-01
dc.identifier.uri http://localhost:8080/xmlui/handle/123456789/3466
dc.description.abstract Head and neck cancer detection using fluorescence spectroscopy from human saliva is reported here. This study has been conducted on squamous cell carcinoma (SCC), and dysplastic (precancer) and control (normal) groups using an in-house developed compact set-up. Fluorescence set-up consists of a 375-nm laser diode and optical components. Spectral bands of flavin adenine dinucleotide (FAD), porphyrins, and Raman are observed in the spectral range of 400 to 800 nm. Presence of FAD and porphyrin bands in human saliva is confirmed by the liquid phantoms of FAD and porphyrin. Significant differences in fluorescence intensities among all the three groups are observed. Three spectral ranges from 455 to 600, 605 to 770, and 400 to 800 nm are selected for each group and area values under each spectral range are computed. To differentiate among the groups, receiver operating characteristic (ROC) analysis is employed on the area values. ROC differentiates among the groups with accuracies of 98%, 92.85%, and 81.13% respectively in the spectral ranges of 400 to 800 nm. However, in other two spectral ranges (455 to 600 and 605 to 770 nm), low accuracy values are found. Obtained accuracy values indicate that selection of human saliva for head and neck cancer detection may be a good alternative. en_US
dc.language.iso en_US en_US
dc.subject Flavin adenine dinucleotide en_US
dc.subject Fluorescence en_US
dc.subject Head and neck cancer en_US
dc.subject Porphyrin en_US
dc.subject Receiver operating characteristic analysis en_US
dc.subject Saliva en_US
dc.title Detection of inaccessible head and neck lesions using human saliva and fluorescence spectroscopy en_US
dc.type Article en_US


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