Access to 5-Substituted 3-Aminofuran/Thiophene-2-Carboxylates from Bifunctional Alkynenitriles

Abstract

An atom-economical approach for the synthesis of 3-aminofurans/thiophenes via a conjugate addition of alcohols and thiols with electron withdrawing groups (EWGs) at α positions on alkynenitriles followed by a modified Thorpe-Ziegler cyclization have been reported. This operationally simple protocol offers a rapid access to a library of 3-aminofurans/thiophenes in moderate to good yields.