Lewis acid-assisted transition metal-free aminocyanation of alkynes with arylamines and N-cyanosuccinimide

dc.contributor.author	Kumar, G.
dc.contributor.author	Bhattacharya, D.
dc.contributor.author	Chatterjee, I.
dc.date.accessioned	2022-09-06T17:40:09Z
dc.date.available	2022-09-06T17:40:09Z
dc.date.issued	2022-09-06
dc.identifier.uri	http://localhost:8080/xmlui/handle/123456789/3965
dc.description.abstract	A transition-metal-free aminocyanation of aryl alkynes has been achieved using indium tribromide, InBr3 or B(C6F5)3 as a Lewis acid. This aminocyanation protocol features with non-toxic cyanide source, a good substrate scope and potentially valuable aminocyanation products. Mechanistic studies reveal the complex formation between Lewis acid and alkyne to produce in situ alkyne nitrile as a key intermediate. Further hydroamination of alkyne nitrile with arylamines affords the E-selective (E:Z=70:30 to 90:10) β-aminoacrylonitrile derivatives.	en_US
dc.language.iso	en_US	en_US
dc.title	Lewis acid-assisted transition metal-free aminocyanation of alkynes with arylamines and N-cyanosuccinimide	en_US
dc.type	Article	en_US