Abstract:
Substituted dihydropyrimidone derivatives were synthesized through one pot multicomponent Zn(ClO4)2
catalysed Biginelli reactions between differently substituted aromatic aldehydes, urea and
ethylacetoacetate. Purified products were characterized and further engineered into metal inorganic
conjugates of silver, copper and gold. Size, morphology and stability of nanoaggregates were analysed
using FTIR, EDX, TEM, XRD and TGA analysis. Antimicrobial activities of all the synthesized compounds
and their metal conjugates were evaluated against various bacterial and fungal strains. Results of
investigations revealed that metal nanoaggregate Au@4c has shown maximum inhibition of MIC 8
against bacteria S. aureus. Further, bacterial SEM cell imaging carried out against S. aureus before and
after treatment of Au@4c advocates that formation of blebs due to the accumulation of the cytoplasm
are possible cause of bacterial cell death.
