Abstract:
A new disulfide-based, imine-linked fluorescent receptor 1 has been synthesized for the highly selective
gratitude of tryptophan (Trp) among the all amino acids investigated in aqueous solutions via synergistic
effects of intermolecular hydrogen bonding and electrostatic interactions. The photophysical properties
of the receptor 1 were evaluated by UV/Vis absorption and fluorescence spectroscopic methods. Receptor
1 selectively recognized tryptophan (Trp) amino acid in DMSO/water with a detection limit down to
47.6 nM. The mechanism of binding was fully validated by computational studies. The theoretical calculations
revealed the role of - stacking as well as hydrogen bonding in binding of tryptophan with
receptor.
