Chiral squaramide-catalyzed enantioselective decarboxylative addition of b-Keto acids to isatin imines

Abstract

An efficient chiral squaramide-catalyzed enantioselective decarboxylative addition reaction of b-keto acids to isatin imines has been developed. The reaction proceeds smoothly using 20 mol% of organocatalyst to afford the chiral 3-aminooxindoles in high yield and excellent enantioselectivities