A highly fluorescent sensor based on hybrid nanoparticles for selective determination of furosemide in aqueous medium

Abstract

The present work depicts the development of a probe based on the organic-inorganic framework that sensitively and selectively recognized furosemide in aqueous medium. An organic receptor 1 is prepared using 1, 8-naphthalic anhydride and diethylenetriamine and the product are further reacted with 1-naphthylisothiocyanate. The receptor is processed into fluorescent organic nanoparticles (FONs); unfortunately, these FONs have not shown any promising sensor activity. The FONs are used as platform for the attachment of gold nanoparticles and the resultant hybrid nanoparticles (H1) are characterized. Hybrid nanoparticles are evaluated for their photophysical studies with fluorescence spectroscopy in aqueous medium and the studies revealed that hybrid nanoparticles selectively recognize furosemide in aqueous medium. The sensor has shown competitive binding for furosemide and no other tested drug has posed any interference in the detection of furosemide. The titrations are performed with furosemide and the lowest detection limit calculated is 551 nM.