Abstract:
Introduction
N-Aryl-, 1-(2-pyridyl)- and 3-(2-thiopyridyl)indoles are ubiquitously found in various
pharmaceuticals, agrochemicals as shown in figure 1. Over the past decades, transition metal
catalyzed C-H activation reactions, metal-free cascade reactions or cross coupling reactions
have been generally employed for their synthesis. Due to the importance of these bioactive
molecules, organic chemists are involved in development of efficient, economical and short
routes for their synthesis from long time. However, the greatest challenge in synthetic
chemistry is the development of a new methodology that can efficiently furnish target
products without creating by-product(s). Therefore, our aim was to develop new
methodologies that can efficiently afford our target compounds [N-Aryl-, 1-(2-pyridyl)-, 3-(2-
thiopyridyl)indoles] without creating any by-product(s) under mild reaction conditions and one
such class of reactions are [2+2+2] cycloadditions. Finally, we have developed transition metal
catalyzed [2+2+2] cycloaddition reaction for the construction of various N-aryl-, 1-(2-pyridyl)-, 3-
(2-thiopyridyl)indoles moieties.
